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KMID : 0043320080310030318
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Archives of Pharmacal Research
2008 Volume.31 No. 3 p.318 ~ p.322
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Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
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Zheng Ming Shan
Hwang Nam-Kyung
Kim Do-Hoon
Moon Tae-Chul
Son Jong-Keun
Chag Hyeun-Wook
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Abstract
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In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, (1), ursolic acid (2), ergosterol peroxide (3), glucoside (4), 2-methoxy-9--D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5-LOX activity with values of 21.04 , 42.30 , 32.82 , and 17.18 , respectively.
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KEYWORD
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Melandrium firmum Rohrbach, Chemical constituents, Cyclooxygenase-2, 5-Lipoxygenase, Anti-inflammatory activity
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